1.Reduces risk of air embolism by more effectively de-airing1,* “I think air embolism is what we fear the most. The use of CarbonAid gives us a CO2 blanket, an extra cover to be able to reduce air embolism.“ Compared to open-ended tubing CO2 delivery in an in vitro mode
	2.CarbonAid and CarbonMini CO2Diffuser devices significantly reduces time for microemboli to disappear2,3 “A lot of the time is spent manipulating the heart, de-airing and evaluating with the echocardiogram when you have air that you have to get rid of. I think that CarbonAid reduces time significantly. When you see the particles disperse and disappear over a period of minutes as opposed to 10 or 15 minutes, I think you can safely say that’s a reduction in the time that you are on bypass. If you don’t think it’s significant, talk to some people and you will see that 15minutes bypass time or whatever additional time that you spend can have pretty adverse effects on patients.”
	3.CO2 Diffuser Device vs. Open-ended Tubing “I’ve tried multiple devices and I was one of those early adopters of the use of CO2 for the removal of cavitary air. I found with the use of CarbonAid versus a simple tube is that it was a much more significant reduction of intracavitary air. And I know from the data and using the actual CarbonAid device is that the CO2is so much more evenly dispersed and that blanket of CO2 that covers the heart reduces the amount of air that you get inside the cavity. So, with the use of open-ended tubing as I would do in the past, I would just perfuse the tube and then CO2 through the IV hose and it didn’t work as well, it actually probably didn’t work at all to be honest with you. “

• Reduces risk of air embolism by more effectively de-airing1,*

  “I think air embolism is what we fear the most. The use of CarbonAid gives us a CO2 blanket, an extra cover to be able to reduce air embolism.“

  Compared to open-ended tubing CO2 delivery in an in vitro mode

• CarbonAid and CarbonMini CO2Diffuser devices significantly reduces time for microemboli to disappear

  “A lot of the time is spent manipulating the heart, de-airing and evaluating with the echocardiogram when you have air that you have to get rid of. I think that CarbonAid reduces time significantly. When you see the particles disperse and disappear over a period of minutes as opposed to 10 or 15 minutes, I think you can safely say that’s a reduction in the time that you are on bypass. If you don’t think it’s significant, talk to some people and you will see that 15minutes bypass time or whatever additional time that you spend can have pretty adverse effects on patients.”

• CO2 Diffuser Device vs. Open-ended Tubing

  “I’ve tried multiple devices and I was one of those early adopters of the use of CO2 for the removal of cavitary air. I found with the use of CarbonAid versus a simple tube is that it was a much more significant reduction of intracavitary air. And I know from the data and using the actual CarbonAid device is that the CO2is so much more evenly dispersed and that blanket of CO2 that covers the heart reduces the amount of air that you get inside the cavity. So, with the use of open-ended tubing as I would do in the past, I would just perfuse the tube and then CO2 through the IV hose and it didn’t work as well, it actually probably didn’t work at all to be honest with you. “

1. Persson and van der Linden. Journal of Cardiothoracic and Vascular Anesthesia 2003;17:329-35.

2. Svernarud et al. Circulation 2004;109:1127-32.

3. Figure 2 in Svernarud et al., median number of microemboli after discontinuation of cardiopulmonary bypass was 0 with CarbonAid at 8 minutes vs. 20 minutes with manual de-airing techniques in 3 areas of interest (left ventricle, left atrium, and proximal part of ascending aorta taken together shown by TEE).

1. Demonstrated Superiority to Other Diffusors

A robust, independent clinical study comparing CO2 field flooding devices, including CarbonAid and other commercial and improvised deairing devices, concluded that the CarbonAid device is superior to other devices or methods.

Comparison of CO2 delivery options from in-vitro experiment data.

When measured at 10L/minute.

2. CarbonAid CO2 Diffusers Provide Near Complete De-Airing

CarbonAid Deairing CO2 Diffuser provided an almost complete de-airing of the model (0.2% remaining air) at flows of 5-10 L/min. This was the result of a uniform distribution of CO2 with a calculated velocity of about 0.1 meter/second.2